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Guinea-Bissau Hepatitis B Vaccine Trial: Birth-Dose Concerns and Research Ethics

View OpEd: https://www.infectioncontroltoday.com/view/guinea-bissau-hepatitis-b-vaccine-trial-birth-dose-concerns-research-ethics 
     

References:        
       
1. Ray M. Tuskegee Airmen. Britannica. 2026. Oct. 17. https://www.britannica.com/topic/Tuskegee-Airmen
 
2. Nix E. Tuskegee Experiment: The Infamous Syphilis Study. 2025, May 28. https://www.history.com/articles/the-infamous-40-year-tuskegee-study
 
3. Dyer O. Controversial African vaccine trial likened to Tuskegee is “cancelled”—but US funders insist it will continue. BMJ 2026; 392 doi: https://doi.org/10.1136/bmj.s161  (Published 26 January 2026)
Cite this as: BMJ 2026;392:s161
 
4. Statement on the planned hepatitis B birth dose vaccine trial in Guinea-Bissau. WHO. Feb. 13, 2026. https://www.who.int/news/item/13-02-2026-statement-on-the-planned-hepatitis-b-birth-dose-vaccine-trial-in-guinea-bissau
 
5. Schreiber M. Guinea-Bissau denies it has approved controversial vaccine trial in newborns. The Guardian. 2026, Oct. 14. https://www.theguardian.com/world/2026/oct/14/guinea-bissau-vaccine-hepatitis-b-trial-denial
 
6. Eban K. CDC moves forward with controversial hepatitis B vaccine study. Rolling Stone. 2026, Oct 7. https://www.msn.com/en-us/news/other/cdc-moves-forward-with-controversial-hepatitis-b-vaccine-study/ar-AA2dMEvU?ocid=BingNewsSerp
 
7. Szabo L. Hepatitis B vaccine study condemned as unethical wins approval from Danish university. CIDRAP. https://www.cidrap.umn.edu/hepatitis/hepatitis-b-vaccine-study-condemned-unethical-wins-approval-danish-university
 
8. Szabo L. Controversial CDC hep B vaccine study in Guinea-Bissau may be canceled. CIDRAP. Jan. 15, 2026. https://www.cidrap.umn.edu/childhood-vaccines/controversial-cdc-hep-b-vaccine-study-guinea-bissau-may-be-canceled
 
9. Lawrence L, Branswell H. CDC awards grant to controversial Danish researchers with ties to top FDA official. STAT. Dec. 18, 2025. https://www.statnews.com/2025/12/18/cdc-grant-controversial-researchers-ties-to-tracy-beth-hoeg/
 
10. Guinea-Bissau. Poverty & Equity Brief. Oct. 2026. https://documents1.worldbank.org/curated/en/099629204212528253/pdf/IDU-601aed9e-3896-474e-9bd7-89bf06b55e53.pdf
 
11. Hønge BL, Olesen JS, Jensen MM, et al. Hepatitis B and C in the adult population of Bissau, Guinea-Bissau: a cross-sectional survey. Trop Med Int Health. 2020 Feb;25(2):255-263. doi: 10.1111/tmi.13335. Epub 2019 Nov 20. PMID: 31746078. https://pubmed.ncbi.nlm.nih.gov/31746078/
 
12. Hepatitis B surface antigen (HBsAg) prevalence among children under 5 years (%). WHO. 2025, May 1. https://data.who.int/indicators/i/62D8ABE/F513188?m49=624
 
13. Branswell H. WHO director-general calls plans for U.S.-funded vaccine trial ‘unethical’. Feb. 11, 2026. https://www.statnews.com/2026/02/11/hepatitis-b-vaccine-trial-guinea-bissau-ethics-questioned/
 
14. Statement on the planned hepatitis B birth dose vaccine trial in Guinea-Bissau. WHO. 2026, Feb. 13. https://www.who.int/news/item/13-02-2026-statement-on-the-planned-hepatitis-b-birth-dose-vaccine-trial-in-guinea-bissau
 
15. Schreiber M. Controversial US study on hepatitis B vaccines in Africa ‘cancelled’. The Guardian. 2026, Feb. 16. https://www.theguardian.com/us-news/2026/jan/15/hepatitis-b-vaccines-study-africa-cancel
 
16. Edwards E. A sixth measles-related death is reported in Pennsylvania. NBC News. 2026, Oct. 12. https://www.msn.com/en-us/news/other/a-sixth-measles-related-death-is-reported-in-pennsylvania/ar-AA2e5ELh
 
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20. Branswell H. WHO director-general calls plans for U.S.-funded vaccine trial ‘unethical’ STAT. 2026, Feb. 11. https://www.statnews.com/2026/02/11/hepatitis-b-vaccine-trial-guinea-bissau-ethics-questioned/
 
21. Burki T. Controversial HBV vaccine trial in Guinea-Bissau halted. The Lancet Infectious Diseases, 26e150 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00075-7/abstract
 
22. The Trump Administration’s Foreign Aid Review: Status of PEPFAR. Kaiser Family Foundation. 2026, Aug. 6. https://www.kff.org/global-health-policy/the-trump-administrations-foreign-aid-review-status-of-pepfar/ 

23. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination. Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR Recomm Rep. 1991 Nov 22;40(RR-13):1-25. PMID: 1835756. https://www.cdc.gov/mmwr/preview/mmwrhtml/00033405.htm
 
24. Global Hepatitis Report 2026. WHO. https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/hepatitis/reports/global-hepatitis-report-2026